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Pathogenesis of hyperinflation in chronic obstructive pulmonary disease

Gagnon Philippe, Guenette Jordan A., Langer Daniel, Laviolette Louis, Mainguy Vincent, Maltais François, Ribeiro Fernanda et Saey Didier. (2014). Pathogenesis of hyperinflation in chronic obstructive pulmonary disease. International Journal of Chronic Obstructive Pulmonary Disease, 9, p. 187-201.

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Résumé

Chronic obstructive pulmonary disease (COPD) is a preventable and treatable lung disease characterized by airflow limitation that is not fully reversible. In a significant proportion of patients with COPD, reduced lung elastic recoil combined with expiratory flow limitation leads to lung hyperinflation during the course of the disease. Development of hyperinflation during the course of COPD is insidious. Dynamic hyperinflation is highly prevalent in the advanced stages of COPD, and new evidence suggests that it also occurs in many patients with mild disease, independently of the presence of resting hyperinflation. Hyperinflation is clinically relevant for patients with COPD mainly because it contributes to dyspnea, exercise intolerance, skeletal muscle limitations, morbidity, and reduced physical activity levels associated with the disease. Various pharmacological and nonpharmacological interventions have been shown to reduce hyperinflation and delay the onset of ventilatory limitation in patients with COPD. The aim of this review is to address the more recent literature regarding the pathogenesis, assessment, and management of both static and dynamic lung hyperinflation in patients with COPD. We also address the influence of biological sex and obesity and new developments in our understanding of hyperinflation in patients with mild COPD and its evolution during progression of the disease.

Type de document:Article publié dans une revue avec comité d'évaluation
Volume:9
Pages:p. 187-201
Version évaluée par les pairs:Oui
Date:2014
Sujets:Sciences de la santé
Sciences de la santé > Sciences de l'activité physique et réadaptation > Physiothérapie
Sciences de la santé > Sciences médicales > Pneumologie
Département, module, service et unité de recherche:Départements et modules > Département des sciences de la santé > Unité d'enseignement en physiothérapie
Mots-clés:Chronic obstructive pulmonary disease, COPD, hyperinflation, expiratory flow limitation, operational lung volumes, bronchopneumopathie chronique obstructive, BPCO, limitation du débit expiratoire, volume pulmonaire opérationnel
Déposé le:02 mars 2016 21:33
Dernière modification:02 févr. 2017 16:46
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