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Routine clinical measures of adiposity as predictors of visceral fat in adolescence : a population-based magnetic resonance imaging study

Goodwin Katie, Syme Catriona, Abrahamowicz Michal, Leonard Gabriel T., Richer Louis, Perron Michel, Veillette Suzanne, Gaudet Daniel, Paus Tomás et Pausova Zdenka. (2013). Routine clinical measures of adiposity as predictors of visceral fat in adolescence : a population-based magnetic resonance imaging study. PLoS ONE, 8, (11),

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URL officielle: http://journals.plos.org/plosone/article?id=10.137...

Résumé

Objective : Visceral fat (VF) increases cardiometabolic risk more than fat stored subcutaneously. Here, we investigated how well routine clinical measures of adiposity, namely body mass index (BMI) and waist circumference (waist), predict VF and subcutaneous fat (SF) in a large population-based sample of adolescents. As body-fat distribution differs between males and females, we performed these analyses separately in each sex.

Design and Methods : VF and SF were measured by magnetic resonance imaging in 1,002 adolescents (482 males, age 12–18 years). Relationships of BMI and waist with VF and SF were tested in multivariable analyses, which adjusted for potentially confounding effects of age and height.

Results : In both males and females, BMI and waist were highly correlated with VF and SF, and explained 55–76% of their total variance. When VF was adjusted for SF, however, BMI and waist explained, respectively, only 0% and 4% of VF variance in males, and 4% and 11% of VF variance in females. In contrast, when SF was adjusted for VF, BMI and waist explained, respectively, 36% and 21% of SF variance in males, and 48% and 23% of SF variance in females. These relationships were similar during early and late puberty.

Conclusions and Relevance : During adolescence, routine clinical measures of adiposity predict well SF but not VF. This holds for both sexes and throughout puberty. Further longitudinal studies are required to assess how well these measures predict changes of VF and SF over time. Given the clinical importance of VF, development of cost-effective imaging techniques and/or robust biomarkers of VF accumulation that would be suitable in everyday clinical practice is warranted.

Type de document:Article publié dans une revue avec comité d'évaluation
Volume:8
Numéro:11
Version évaluée par les pairs:Oui
Date:Novembre 2013
Sujets:Sciences de la santé
Sciences de la santé > Sciences médicales
Département, module, service et unité de recherche:Départements et modules > Département des sciences de la santé > Module de psychologie
Mots-clés:Puberty, adolescence, obesity, body mass index, magnetic resonance imaging, anthropometry, adipose tissue, puberté, obésité, indice de masse corporelle, imagerie par résonance magnétique, IRM, anthropométrie, tissus adipeux
Déposé le:20 avr. 2016 22:22
Dernière modification:25 nov. 2016 18:22
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