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Growth of white matter in the adolescent brain: role of testosterone and androgen receptor

Perrin Jennifer S., Hervé Pierre-Yves, Leonard Gabriel, Perron Michel, Pike G. Bruce, Pitiot Alain, Richer Louis, Veillette Suzanne, Pausova Zdenka et Paus Tomás. (2008). Growth of white matter in the adolescent brain: role of testosterone and androgen receptor. The Journal of Neuroscience, 28, (38), p. 9519-9524.

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URL officielle: http://www.jneurosci.org/content/28/38/9519.full

Résumé

The growth of white matter during human adolescence shows a striking sexual dimorphism; the volume of white matter increases with age slightly in girls and steeply in boys. Here, we provide evidence supporting the role of androgen receptor (AR) in mediating the effect of testosterone on white matter. In a large sample of typically developing adolescents (n = 408, 204 males), we used magnetic resonance imaging and acquired T1-weighted and magnetization transfer ratio (MTR) images. We also measured plasma levels of testosterone and genotyped a functional polymorphism in the AR gene, namely the number of CAG repeats in exon 1 believed to be inversely proportional to the AR transcriptional activity. We found that the testosterone-related increase of white-matter volume was stronger in male adolescents with the lower versus higher number of CAG repeats in the AR gene, with testosterone explaining, respectively, 26 and 8% of variance in the volume. The MTR results suggest that this growth is not related to myelination; the MTR decreased with age in male adolescents. We speculate that testosterone affects axonal caliber rather than the thickness of the myelin sheath.

Type de document:Article publié dans une revue avec comité d'évaluation
Volume:28
Numéro:38
Pages:p. 9519-9524
Version évaluée par les pairs:Oui
Date:17 Septembre 2008
Sujets:Sciences de la santé
Sciences de la santé > Sciences médicales > Génétique
Sciences de la santé > Sciences médicales > Neurosciences
Département, module, service et unité de recherche:Départements et modules > Département des sciences de la santé > Module de psychologie
Mots-clés:adolescence, brain, MRI, magnetic resonance imaging, myelination, depression, axonal caliber, cerveau, IRM, imagerie par résonance magnétique, myélinisation
Déposé le:20 avr. 2016 21:32
Dernière modification:25 nov. 2016 18:23
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