LiveZilla Live Chat Software

Constellation, le dépôt institutionnel de l'Université du Québec à Chicoutimi

Combining omics data to identify genes associated with allergic rhinitis

Morin Andréanne, Laviolette Michel, Pastinen Tomi, Boulet Louis-Philippe et Laprise Catherine. (2017). Combining omics data to identify genes associated with allergic rhinitis. Clinical Epigenetics, 9, (1), p. 1-6.

[img]
Prévisualisation
PDF - Version publiée
Disponible sous licence Creative Commons Attribution.

526kB

URL officielle: http://dx.doi.org/doi:10.1186/s13148-017-0310-1

Résumé

Allergic rhinitis is a common chronic disorder characterized by immunoglobulin E-mediated inflammation. To identify new genes associated with this trait, we performed genome- and epigenome-wide association studies and linked marginally significant CpGs located in genes or its promoter and SNPs located 1 Mb from the CpGs, by identifying cis methylation quantitative trait loci (mQTL). This approach relies on functional cellular aspects rather than stringent statistical correction. We were able to identify one gene with significant cis-mQTL for allergic rhinitis, caudal-type homeobox 1 (CDX1). We also identified 11 genes with marginally significant cis-mQTLs (p < 0.05) including one with both allergic rhinitis with or without asthma (RNF39). Moreover, most SNPs identified were not located closest to the gene they were linked to through cis-mQTLs counting the one linked to CDX1 located in a gene previously associated with asthma and atopic dermatitis. By combining omics data, we were able to identify new genes associated with allergic rhinitis and better assess the genes linked to associated SNPs.

Type de document:Article publié dans une revue avec comité d'évaluation
Volume:9
Numéro:1
Pages:p. 1-6
Version évaluée par les pairs:Oui
Date:2017
Sujets:Sciences de la santé > Sciences médicales > Biologie moléculaire
Sciences de la santé > Sciences médicales > Génétique
Département, module, service et unité de recherche:Départements et modules > Département des sciences fondamentales
Mots-clés:Allergic rhinitis, asthma, EWAS, epigenome-wide association study, GWAS, genome-wide association study, mQTLs, methylation quantitative trait loci, omics
Informations complémentaires:Creative Commons Attribution 4.0
Déposé le:05 avr. 2017 20:53
Dernière modification:05 avr. 2017 21:08
Afficher les statistiques de telechargements

Éditer le document (administrateurs uniquement)

Creative Commons LicenseSauf indication contraire, les documents archivés dans Constellation sont rendus disponibles selon les termes de la licence Creative Commons "Paternité, pas d'utilisation commerciale, pas de modification" 2.5 Canada.

Bibliothèque Paul-Émile-Boulet, UQAC
555, boulevard de l'Université
Chicoutimi (Québec)  CANADA G7H 2B1
418 545-5011, poste 5630