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Income inequality, gene expression, and brain maturation during adolescence

Parker Nadine, Wong Angelica P., Leonard Gabriel, Perron Michel, Pike Bruce, Richer Louis, Veillette Suzanne, Pausova Zdenka et Paus Tomás. (2017). Income inequality, gene expression, and brain maturation during adolescence. Scientific Reports, 7, (1), p. 7397.

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URL officielle: http://dx.doi.org/10.1038/s41598-017-07735-2

Résumé

Income inequality is associated with poor health and social outcomes. Negative social comparisons and competition may involve the hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axes in underlying some of these complex inter-relationships. Here we investigate brain maturation, indexed by age-related decreases in cortical thickness, in adolescents living in neighborhoods with differing levels of income inequality and household income. We examine whether inter-regional variations relate to those in glucocorticoid receptor (HPA) and androgen receptor (HPG) gene expression. For each sex, we used a median split of income inequality and household income (income-to-needs ratio) to create four subgroups. In female adolescents, the high-inequality low-income group displayed the greatest age-related decreases in cortical thickness. In this group, expression of glucocorticoid and androgen receptor genes explained the most variance in these age-related decreases in thickness across the cortex. We speculate that female adolescents living in high-inequality neighborhoods and low-income households may experience greater HPA and HPG activity, leading to steeper decreases in cortical thickness with age.

Type de document:Article publié dans une revue avec comité d'évaluation
Volume:7
Numéro:1
Pages:p. 7397
Version évaluée par les pairs:Oui
Date:2017
Sujets:Sciences sociales et humaines > Sciences sociales
Sciences sociales et humaines > Sciences sociales > Psychologie
Sciences de la santé
Sciences de la santé > Sciences médicales > Génétique
Département, module, service et unité de recherche:Départements et modules > Département des sciences de la santé > Module de psychologie
Mots-clés:Adolescence, adolescents, brain maturation, income, glucocorticoid receptor (HPA), androgen receptor (HPG), cortical thickness, maturité du cerveau, revenu, récepteurs aux glucocorticoïdes, récepteurs aux androgènes, épaisseur corticale
Déposé le:24 oct. 2017 00:06
Dernière modification:24 oct. 2017 00:06
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Creative Commons LicenseSauf indication contraire, les documents archivés dans Constellation sont rendus disponibles selon les termes de la licence Creative Commons "Paternité, pas d'utilisation commerciale, pas de modification" 2.5 Canada.

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