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Chronic insomnia and immune functioning

Savard Josée, Laroche Liny, Simard Sébastien, Ivers Hans et Morin Charles M.. (2003). Chronic insomnia and immune functioning. Psychosomatic Medicine, 65, (2), p. 211-221.

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URL officielle: http://dx.doi.org/10.1097/01.PSY.0000033126.22740....

Résumé

Objective: The goal of this study was to investigate whether clinical insomnia is associated with immune alterations by comparing immune functioning between patients with chronic insomnia and good sleepers.

Methods: The good sleepers group was composed of 19 adults with a regular sleep schedule and no complaint of sleep disturbances. The insomnia group was composed of 17 adults meeting criteria for a chronic primary insomnia disorder. Peripheral blood samples were taken at the interview (time 1) and before the second night of polysomnographic assessment (time 2) for immune measures, including enumeration of blood cell counts (ie, white blood cells, monocytes, lymphocytes, and CD3+, CD4+, CD8+, and CD16+/CD56+ cells), natural killer cell activity, and cytokine production (ie, interleukin-1β, interleukin-2, and interferon gamma).

Results: Significant between-group differences were observed for CD3+, CD4+, and CD8+ cells, with higher levels found in good sleepers. In addition, a significant group-by-time interaction was found on monocyte counts. Although this was the only significant interaction effect observed, between-group differences were greater at time 2.

Conclusions: This study suggests that chronic insomnia is associated with some immune alterations. More research is needed to determine the clinical significance of these findings.

Type de document:Article publié dans une revue avec comité d'évaluation
Volume:65
Numéro:2
Pages:p. 211-221
Version évaluée par les pairs:Oui
Date:2003
Sujets:Sciences sociales et humaines > Sciences sociales > Psychologie
Sciences de la santé
Sciences de la santé > Sciences médicales
Département, module, service et unité de recherche:Départements et modules > Département des sciences de la santé > Module de psychologie
Mots-clés:insomnia, immune functioning, chronic, sleep, insomnie, fonctionnement immunitaire, chronique, sommeil.
Déposé le:11 janv. 2018 16:26
Dernière modification:11 janv. 2018 16:26
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