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Prenatal exposure to maternal cigarette smoking, amygdala volume, and fat intake in adolescence

Haghighi Amirreza, Schwartz Deborah H., Abrahamowicz Michal, Leonard Gabriel T., Perron Michel, Richer Louis, Veillette Suzanne, Gaudet Daniel, Paus Tomás et Pausova Zdenka. (2013). Prenatal exposure to maternal cigarette smoking, amygdala volume, and fat intake in adolescence. JAMA Psychiatry, 70, (1), p. 98-105.

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Context : Prenatal exposure to maternal cigarette smoking is a well-established risk factor for obesity, but the underlying mechanisms are not known. Preference for fatty foods, regulated in part by the brain reward system, may contribute to the development of obesity.

Objective : To examine whether prenatal exposure to maternal cigarette smoking is associated with enhanced fat intake and risk for obesity, and whether these associations may be related to subtle structural variations in brain regions involved in reward processing.

Design : Cross-sectional study of a population-based cohort.

Setting : The Saguenay Youth Study, Quebec, Canada.

Participants : A total of 378 adolescents (aged 13 to 19 years; Tanner stage 4 and 5 of sexual maturation), half of whom were exposed prenatally to maternal cigarette smoking (mean [SD], 11.1 [6.8] cigarettes/d).

Main Outcome Measures : Fat intake was assessed with a 24-hour food recall (percentage of energy intake consumed as fat). Body adiposity was measured with anthropometry and multifrequency bioimpedance. Volumes of key brain structures involved in reward processing, namely the amygdala, nucleus accumbens, and orbitofrontal cortex, were measured with magnetic resonance imaging.

Results : Exposed vs nonexposed subjects exhibited a higher total body fat (by approximately 1.7 kg; P = .009) and fat intake (by 2.7%; P = .001). They also exhibited a lower volume of the amygdala (by 95 mm3; P < .001) but not of the other 2 brain structures. Consistent with its possible role in limiting fat intake, amygdala volume correlated inversely with fat intake (r = −0.15; P = .006).

Conclusions : Prenatal exposure to maternal cigarette smoking may promote obesity by enhancing dietary preference for fat, and this effect may be mediated in part through subtle structural variations in the amygdala.

Type de document:Article publié dans une revue avec comité d'évaluation
Pages:p. 98-105
Version évaluée par les pairs:Oui
Date:Janvier 2013
Sujets:Sciences de la santé
Sciences de la santé > Sciences médicales > Neurosciences
Département, module, service et unité de recherche:Départements et modules > Département des sciences de la santé > Module de psychologie
Mots-clés:Prenatal maternal cigarette smoking, obesity, adolescence, fat intake, tabagisme maternel prénatal, obésité, apport en graisse
Déposé le:20 avr. 2016 22:37
Dernière modification:25 nov. 2016 18:21
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