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Randomized clinical trial on cognitive therapy for depression in women with metastatic breast cancer : psychological and immunological effects

Savard Josée, Simard Sébastien, Giguère Isabelle, Ivers Hans, Morin Charles M., Maunsell Elizabeth, Gagnon Pierre, Robert Jean et Marceau Danièle. (2006). Randomized clinical trial on cognitive therapy for depression in women with metastatic breast cancer : psychological and immunological effects. Palliative and Supportive Care, 4, (3), p. 219-237.

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Objective: Depression is particularly prevalent in patients with advanced cancer. Cognitive therapy (CT) is an empirically supported treatment for depression in the general population. However, efficacy remains to be demonstrated in patients with advanced cancer. A prior controlled trial of CT in a group format showed improvements in depression, mood disturbance, and self-esteem; however, these effects were not maintained over time. Studies examining the efficacy of individual format CT interventions that may ensure more long-term maintenance of benefits are necessary. This study assessed the efficacy of CT for depression administered individually in women with metastatic breast cancer and its effect on immune function.

Method: Forty-five women were randomly assigned to either individual CT or to a waiting-list control (WLC) condition. CT was composed of eight weekly sessions of CT and three booster sessions administered at 3-week intervals following the end of treatment.

Results: Patients treated with CT had significantly lower scores on the Hamilton Depression Rating Scale at posttreatment compared to untreated patients. Pooled data from both groups indicated significant reductions of depressive symptoms from pre- to posttreatment, as well as reduction of associated symptoms including anxiety, fatigue, and insomnia symptoms. These effects were well sustained at the 3- and 6-month follow-up evaluations. CT for depression did not appear to have a significant impact on immune functioning.

Significance of results: Findings of this study support the efficacy of CT for depression in this population and suggest that the administration of individual and booster sessions after treatment termination may be instrumental in sustaining the treatment effects over time.

Type de document:Article publié dans une revue avec comité d'évaluation
Pages:p. 219-237
Version évaluée par les pairs:Oui
Date:Septembre 2006
Sujets:Sciences sociales et humaines > Sciences sociales > Psychologie
Sciences de la santé
Sciences de la santé > Sciences médicales > Oncologie
Département, module, service et unité de recherche:Départements et modules > Département des sciences de la santé > Module de psychologie
Mots-clés:metastatic breast cancer, cognitive therapy, depression, immunity, cancer du sein, thérapie cognitive, dépression, cancer du sein métastatique
Déposé le:20 déc. 2017 22:13
Dernière modification:20 déc. 2017 22:13
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