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Effect of psychological intervention on fear of cancer recurrence: A systematic review and meta-analysis

Tauber Nina M., O’Toole Mia S., Dinkel Andreas, Galica Jacqueline, Humphris Gerry, Lebel Sophie, Maheu Christine, Ozakinci Gozde, Prins Judith, Sharpe Louise, Smith Allan “Ben”, Thewes Belinda, Simard Sébastien et Zachariae Robert. (2019). Effect of psychological intervention on fear of cancer recurrence: A systematic review and meta-analysis. Journal of Clinical Oncology, 37, (31), p. 2899-2915.

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PURPOSE: Fear of cancer recurrence (FCR) is a significantly distressing problem that affects a substantial number of patients with and survivors of cancer; however, the overall efficacy of available psychological interventions on FCR remains unknown. We therefore evaluated this in the present systematic review and meta-analysis.

METHODS: We searched key electronic databases to identify trials that evaluated the effect of psychological interventions on FCR among patients with and survivors of cancer. Controlled trials were subjected to meta-analysis, and the moderating influence of study characteristics on the effect were examined. Overall quality of evidence was evaluated using the GRADE system. Open trials were narratively reviewed to explore ongoing developments in the field (PROSPERO registration no.: CRD42017076514).

RESULTS: A total of 23 controlled trials (21 randomized controlled trials) and nine open trials were included. Small effects (Hedges’s g) were found both at postintervention (g = 0.33; 95% CI, 0.20 to 0.46; P < .001) and at follow-up (g = 0.28; 95% CI, 0.17 to 0.40; P < .001). Effects at postintervention of contemporary cognitive behavioral therapies (CBTs; g = 0.42) were larger than those of traditional CBTs (g = 0.24; β = .22; 95% CI, .04 to .41; P = .018). At follow-up, larger effects were associated with shorter time to follow-up (β = −.01; 95% CI, −.01 to −.00; P = .027) and group-based formats (β = .18; 95% CI, .01 to .36; P = .041). A GRADE evaluation indicated evidence of moderate strength for effects of psychological intervention for FCR.

CONCLUSION: Psychological interventions for FCR revealed a small but robust effect at postintervention, which was largely maintained at follow-up. Larger postintervention effects were found for contemporary CBTs that were focused on processes of cognition—for example, worry, rumination, and attentional bias—rather than the content, and aimed to change the way in which the individual relates to his or her inner experiences. Future trials could investigate how to further optimize and tailor interventions to individual patients’ FCR presentation.

Type de document:Article publié dans une revue avec comité d'évaluation
Pages:p. 2899-2915
Version évaluée par les pairs:Oui
Identifiant unique:10.1200/JCO.19.00572
Sujets:Sciences sociales et humaines > Sciences sociales > Psychologie
Sciences de la santé
Sciences de la santé > Sciences médicales
Sciences de la santé > Sciences médicales > Oncologie
Département, module, service et unité de recherche:Départements et modules > Département des sciences de la santé > Module de psychologie
Mots-clés:psychological adaptation, cancer survivors, cognitive behavioral therapy, fear, neoplasm, reccurence, adaptation psychologique, survivants du cancer, thérapie cognitive, peur, récidive tumorale, trouble phobique
Déposé le:25 févr. 2021 21:06
Dernière modification:25 févr. 2021 21:06
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