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Particular Mal de Meleda phenotypes in Tunisia and mutations founder effect in the Mediterranean region

Bchetnia Mbarka, Laroussi Nadia, Youssef Monia, Charfeddine Cherine, Ben Brick Ahlem Sabrine, Boubaker Mohamed Samir, Mokni Mourad, Abdelhak Sonia, Zili Jameleddine et Benmously Rym. (2013). Particular Mal de Meleda phenotypes in Tunisia and mutations founder effect in the Mediterranean region. BioMed Research International, 2013, e206803.

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URL officielle: http://dx.doi.org/doi:10.1155/2013/206803

Résumé

Mal de Meleda (MDM) is a rare, autosomal recessive form of palmoplantar keratoderma. It is characterized by erythema and hyperkeratosis of the palms and soles that progressively extend to the dorsal surface of the hands and feet. It is caused by mutations in SLURP-1 gene encoding for secreted mammalian Ly-6/uPAR-related protein 1 (SLURP-1). We performed mutational analysis by direct sequencing of SLURP-1 gene in order to identify the genetic defect in three unrelated families (families MDM-12, MDM-13, and MDM-14) variably affected with transgressive palmoplantar keratoderma. A spectrum of clinical presentations with variable features has been observed from the pronounced to the transparent hyperkeratosis. We identified the 82delT frame shift mutation in the SLURP-1 gene in both families MDM-12 and MDM-13 and the missense variation p.Cys99Tyr in family MDM-14. To date, the 82delT variation is the most frequent cause of MDM in the world which is in favour of a recurrent molecular defect. The p.Cys99Tyr variation is only described in Tunisian families making evidence of founder effect mutation of likely Tunisian origin. Our patients presented with very severe to relatively mild phenotypes, including multiple keratolytic pits observed for one patient in the hyperkeratotic area which was not previously reported. The phenotypic variability may reflect the influence of additional factors on disease characteristics. This report further expands the spectrum of clinical phenotypes associated with mutations in SLURP1 in the Mediterranean population.

Type de document:Article publié dans une revue avec comité d'évaluation
ISSN:2314-6133
Volume:2013
Pages:e206803
Version évaluée par les pairs:Oui
Date:2013
Identifiant unique:10.1155/2013/206803
Sujets:Sciences de la santé > Sciences médicales > Dermatologie
Sciences de la santé > Sciences médicales > Génétique
Département, module, service et unité de recherche:Départements et modules > Département des sciences fondamentales
Mots-clés:Mal de Meleda, genetics, founder effect, mutation
Déposé le:14 juill. 2021 12:58
Dernière modification:14 juill. 2021 12:58
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