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Could the epigenetics of eosinophils in asthma and allergy solve parts of the puzzle?

Bélanger Émile et Laprise Catherine. (2021). Could the epigenetics of eosinophils in asthma and allergy solve parts of the puzzle? International Journal of Molecular Sciences, 22, (16), e8921.

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URL officielle: http://dx.doi.org/doi:10.3390/ijms22168921

Résumé

Epigenetics is a field of study investigating changes in gene expression that do not alter the DNA sequence. These changes are often influenced by environmental or social factors and are reversible. Epigenetic mechanisms include DNA methylation, histone modification, and noncoding RNA. Understanding the role of these epigenetic mechanisms in human diseases provides useful information with regard to disease severity and development. Several studies have searched for the epigenetic mechanisms that regulate allergies and asthma; however, only few studies have used samples of eosinophil, a proinflammatory cell type known to be largely recruited during allergic or asthmatic inflammation. Such studies would enable us to better understand the factors that influence the massive recruitment of eosinophils during allergic and asthmatic symptoms. In this review, we sought to summarize different studies that aimed to discover differential patterns of histone modifications, DNA methylation, and noncoding RNAs in eosinophil samples of individuals with certain diseases, with a particular focus on those with asthma or allergic diseases.

Type de document:Article publié dans une revue avec comité d'évaluation
ISSN:1422-0067
Volume:22
Numéro:16
Pages:e8921
Version évaluée par les pairs:Oui
Date:2021
Identifiant unique:10.3390/ijms22168921
Sujets:Sciences de la santé > Sciences médicales > Biologie moléculaire
Sciences de la santé > Sciences médicales > Génétique
Département, module, service et unité de recherche:Départements et modules > Département des sciences fondamentales
Mots-clés:eosinophils, allergies, asthma, hypereosinophilia, methylation, microRNA, miRNA, epigenetics
Déposé le:09 mai 2022 17:10
Dernière modification:09 mai 2022 17:10
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