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Chemical composition and anti-herpes simplex virus type 1 (HSV-1) activity of extracts from Cornus canadensis

Lavoie Serge, Côté Isabelle, Pichette André, Gauthier Charles, Ouellet Michaël, Nagau-Lavoie Francine, Mshvildadze Vakhtang et Legault Jean. (2017). Chemical composition and anti-herpes simplex virus type 1 (HSV-1) activity of extracts from Cornus canadensis. BMC Complementary and Alternative Medicine, 17,

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URL officielle: http://dx.doi.org/doi:10.1186/s12906-017-1618-2

Résumé

Background Many plants of boreal forest of Quebec have been used by Native Americans to treat a variety of microbial infections. However, the antiviral activities of these plants have been seldom evaluated on cellular models to validate their in vitro efficiencies. In this study, Cornus canadensis L. (Cornaceae), a plant used in Native American traditional medicine to treat possible antiviral infections, has been selected for further examination.

Methods The plant was extracted by decoction and infusion with water, water/ethanol 1:1 and ethanol to obtain extracts similar to those used by Native Americans. The effects of the extracts were tested on herpes simplex virus type-1 (HSV-1) using a plaque reduction assay. Moreover, bioassay-guided fractionation was achieved to isolate bioactive compounds.

Results Water/ethanol 1:1 infusion of C. canadensis leaves were the most active extracts to inhibit virus absorption with EC50 of about 9 μg mL−1, whereas for direct mode, both extraction methods using water or water/ethanol 1:1 as solvent were relatively similar with EC50 ranging from 11 to 17 μg mL−1. The fractionation led to the identification of active fractions containing hydrolysable tannins. Tellimagrandin I was found the most active compound with an EC50 of 2.6 μM for the direct mode and 5.0 μM for the absorption mode.

Conclusion Altogether, the results presented in this work support the antiviral activity of Cornus canadensis used in Native American traditional medicine.

Type de document:Article publié dans une revue avec comité d'évaluation
ISSN:1472-6882
Volume:17
Version évaluée par les pairs:Oui
Date:2017
Identifiant unique:10.1186/s12906-017-1618-2
Sujets:Sciences naturelles et génie > Sciences naturelles > Chimie
Sciences de la santé > Sciences médicales > Pharmacologie
Département, module, service et unité de recherche:Départements et modules > Département des sciences fondamentales
Mots-clés:Traditional medicine, native american, cornus canadensis, HSV-1, hydrolysable tannins, tellimagrandin I
Déposé le:01 sept. 2021 18:37
Dernière modification:01 sept. 2021 18:37
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Creative Commons LicenseSauf indication contraire, les documents archivés dans Constellation sont rendus disponibles selon les termes de la licence Creative Commons "Paternité, pas d'utilisation commerciale, pas de modification" 2.5 Canada.

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