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Cytotoxic steroidal saponins from the flowers of Allium leucanthum

Mskhiladze Lasha, Legault Jean, Lavoie Serge, Mshvildadze Vakhtang, Kuchukhidze Jumber, Elias Riad et Pichette André. (2008). Cytotoxic steroidal saponins from the flowers of Allium leucanthum. Molecules, 13, (12), p. 2925-2934.

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URL officielle: http://dx.doi.org/doi:10.3390/molecules13122925

Résumé

Allium leucanthum C. Koch is an endemic Caucasian species that grows in Georgia. The flowers are used in traditional medicine. Phytochemical investigation allowed the isolation of seven spirostanol type saponins from the flowers. Their structures were elucidated on the base of NMR and HRESIMS spectrometry data. A new compound, which we have named leucospiroside A (5), has been identified as (25R)-5α-spirostane-2α,3β,6β-triol 3-O-β-glucopyranosyl-(1→3)-β-glucopyranosyl-(1→2)-[β-glucopyranosyl-(1→3)]-β-glucopyranosyl-(1→4)-β-galactopyranoside. The six others were known substances, but are described in this plant for the first time. The crude extract, spirostanol and furostanol fractions, as well as isolated compounds, were evaluated for their in vitro cytotoxic activity. Compounds 1-3 and 5 were found to be the most active, with relatively similar IC50 values ranging from 3.7 to 5.8 μM for a lung cancer cell line (A549) and 5.6 to 8.2 μM for a colon cancer cell line (DLD-1).

Type de document:Article publié dans une revue avec comité d'évaluation
ISSN:1420-3049
Volume:13
Numéro:12
Pages:p. 2925-2934
Version évaluée par les pairs:Oui
Date:2008
Identifiant unique:10.3390/molecules13122925
Sujets:Sciences naturelles et génie > Sciences naturelles > Biologie et autres sciences connexes
Sciences naturelles et génie > Sciences naturelles > Chimie
Département, module, service et unité de recherche:Départements et modules > Département des sciences fondamentales
Mots-clés:Allium leucathum, Spirostane saponins, structure determination, cytotoxic activity
Déposé le:01 sept. 2021 19:07
Dernière modification:01 sept. 2021 19:07
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