Simard François, Legault Jean, Lavoie Serge, Mshvildadze Vakhtang et Pichette André. (2008). Isolation and identification of cytotoxic compounds from the wood of Pinus resinosa. Phytotherapy Research, 22, (7), p. 919-922.
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URL officielle: http://dx.doi.org/doi:10.1002/ptr.2416
Résumé
Methanol extracts of wood from Pinus resinosa were found to be selectively cytotoxic against human lung carcinoma cells, A549 (IC50 41 +/- 6 microg/mL), human colorectal adenocarcinoma cells, DLD-1 (IC50 47 +/- 4 microg/mL) in comparison with healthy cells, WS1 (IC50 130 +/- 11 microg/mL). Five known compounds were isolated and identified by 1H, 13C NMRspectroscopy and HR-ESI-MS mass spectrometry as, pinosylvin monomethyl ether (1), pinosylvin (2), pinosylvin dimethyl ether (3), pinobanksin (4) and (-)-norachelogenin (5). Compound 4 was isolated for the first time in P. resinosa. The cytotoxicity of compounds 1-5 was evaluated against A549, DLD-1 and WS1. Compound 1 exhibited the strongest cytotoxicity against both tumor cell lines and the healthy cell line with an IC50 of 25 +/- 4 microm for A549, 20 +/- 1 microm for DLD-1 and 34 +/- 3 microm for WS1.
| Type de document: | Article publié dans une revue avec comité d'évaluation |
|---|---|
| ISSN: | 0951418X |
| Volume: | 22 |
| Numéro: | 7 |
| Pages: | p. 919-922 |
| Version évaluée par les pairs: | Oui |
| Date: | 2008 |
| Identifiant unique: | 10.1002/ptr.2416 |
| Sujets: | Sciences naturelles et génie > Sciences naturelles > Biologie et autres sciences connexes Sciences naturelles et génie > Sciences naturelles > Chimie Sciences de la santé > Sciences médicales > Pharmacologie |
| Département, module, service et unité de recherche: | Départements et modules > Département des sciences fondamentales |
| Mots-clés: | Pinus resinosa, stilbene, bioassay-guided isolation, cytotoxic |
| Déposé le: | 10 nov. 2021 21:53 |
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| Dernière modification: | 10 nov. 2021 21:53 |
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