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Composition and cytotoxic activity of the leaf essential oil of Comptonia peregrina (L.) Coulter

Sylvestre Muriel, Pichette André, Lavoie Serge, Longtin Angélique et Legault Jean. (2007). Composition and cytotoxic activity of the leaf essential oil of Comptonia peregrina (L.) Coulter. Phytotherapy Research, 21, (6), p. 536-540.

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URL officielle: http://dx.doi.org/doi:10.1002/ptr.2095

Résumé

Comptonia peregrina (L.) Coulter, a native plant from Canada used in traditional medicine against cancer, was extracted by hydrodistillation. Two fractions were collected, one over 0-30 min and one over 30-60 min, to assess the influence of time of hydrodistillation on the composition of essential oil. The chemical composition of these two extracts was determined by GC and GC-MS analyses. Fifty five components were identified: beta-caryophyllene (23.69% and 15.16%) and alpha-humulene (9.67% and 7.43%) were the major components in the 0-30 min and 30-60 min fractions, respectively, while beta-myrcene was detected in a higher amount in the 0-30 min fraction (12.58%) than in the 30-60 min fraction (0.15%). The cytotoxic activities of these fractions were assessed against human lung carcinoma cell line A-549 and human colon adenocarcinoma cell line DLD-1. Only the 30-60 min fraction was found to be active against both tumor cell lines, with GI(50) values of 66 +/- 12 microg/mL for A-549 and of 46 +/- 7 microg/mL for DLD-1. Two sesquiterpenes present in the oil, alpha-humulene and (E)-nerolidol, have been found to be cytotoxic against both tumor cell lines.

Type de document:Article publié dans une revue avec comité d'évaluation
ISSN:0951418X
Volume:21
Numéro:6
Pages:p. 536-540
Version évaluée par les pairs:Oui
Date:2007
Identifiant unique:10.1002/ptr.2095
Sujets:Sciences naturelles et génie > Sciences naturelles > Biologie et autres sciences connexes
Sciences naturelles et génie > Sciences naturelles > Chimie
Sciences de la santé > Sciences médicales > Pharmacologie
Département, module, service et unité de recherche:Départements et modules > Département des sciences fondamentales
Mots-clés:Comptonia peregrina, essential oil, (E)-nerolidol, α-humulene, cytotoxic activity
Déposé le:10 nov. 2021 22:13
Dernière modification:10 nov. 2021 22:13
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