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The Biobanque québécoise de la COVID-19 (BQC19)—A cohort to prospectively study the clinical and biological determinants of COVID-19 clinical trajectories

Lambert John S., Tremblay Karine, Rousseau Simon, Zawati Ma’n H., Auld Daniel, Chassé Michaël, Coderre Daniel, Falcone Emilia Liana, Gauthier Nicolas, Grandvaux Nathalie, Gros-Louis François, Jabet Carole, Joly Yann, Kaufmann Daniel E., Laprise Catherine, Larochelle Catherine, Maltais François, Mes-Masson Anne-Marie, Montpetit Alexandre, Piché Alain, Richards J. Brent, Tse Sze Man, Turgeon Alexis F., Turecki Gustavo, Vinh Donald C., Wang Han Ting et Mooser Vincent. (2021). The Biobanque québécoise de la COVID-19 (BQC19)—A cohort to prospectively study the clinical and biological determinants of COVID-19 clinical trajectories. PLoS ONE, 16, (5), e0245031.

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URL officielle: http://dx.doi.org/doi:10.1371/journal.pone.0245031

Résumé

SARS-CoV-2 infection causing the novel coronavirus disease 2019 (COVID–19) has been responsible for more than 2.8 million deaths and nearly 125 million infections worldwide as of March 2021. In March 2020, the World Health Organization determined that the COVID–19 outbreak is a global pandemic. The urgency and magnitude of this pandemic demanded immediate action and coordination between local, regional, national, and international actors. In that mission, researchers require access to high-quality biological materials and data from SARS-CoV-2 infected and uninfected patients, covering the spectrum of disease manifestations. The “Biobanque québécoise de la COVID-19” (BQC19) is a pan–provincial initiative undertaken in Québec, Canada to enable the collection, storage and sharing of samples and data related to the COVID-19 crisis. As a disease-oriented biobank based on high-quality biosamples and clinical data of hospitalized and non-hospitalized SARS-CoV-2 PCR positive and negative individuals. The BQC19 follows a legal and ethical management framework approved by local health authorities. The biosamples include plasma, serum, peripheral blood mononuclear cells and DNA and RNA isolated from whole blood. In addition to the clinical variables, BQC19 will provide in-depth analytical data derived from the biosamples including whole genome and transcriptome sequencing, proteome and metabolome analyses, multiplex measurements of key circulating markers as well as anti-SARS-CoV-2 antibody responses. BQC19 will provide the scientific and medical communities access to data and samples to better understand, manage and ultimately limit, the impact of COVID-19. In this paper we present BQC19, describe the process according to which it is governed and organized, and address opportunities for future research collaborations. BQC19 aims to be a part of a global communal effort addressing the challenges of COVID–19.

Type de document:Article publié dans une revue avec comité d'évaluation
ISSN:1932-6203
Volume:16
Numéro:5
Pages:e0245031
Version évaluée par les pairs:Oui
Date:2021
Identifiant unique:10.1371/journal.pone.0245031
Sujets:Sciences de la santé > Sciences médicales > Génétique
Département, module, service et unité de recherche:Départements et modules > Département des sciences fondamentales
Mots-clés:Biological specimen banks, COVID-19, Humans, information dissemination, pandemics, Quebec, SARS-CoV-2
Déposé le:09 mai 2022 18:36
Dernière modification:09 mai 2022 18:36
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