Côté Claude H., Tremblay Marie-Hélène, Duchesne Élise et Lapoite Benoît M.. (2008). Inflammation-induced leukocyte accumulation in injured skeletal muscle: role of mast cells. Muscle & Nerve, 37, (6), p. 754-763.
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URL officielle: https://doi.org/10.1002/mus.20998
Résumé
Inflammation consequent to muscle damage is characterized by an accumulation of leukocytes. Our aim in this study was to determine whether mast cells can modulate inflammation‐induced leukocyte trafficking. One approach consisted of giving rats a mast cell–degranulating agent, CMP 48/80, prior to a protocol of lengthening contractions inducing inflammation without neutrophil accumulation; in parallel, other rats were given the mast cell–stabilizing agent, cromolyn, prior to injecting muscle with bupivacaine, which induces neutrophil accumulation. Damage was evaluated through measurement of contractile force and inflammation using histochemical and immunohistochemichal methods. Stimulation with CMP 48/80 increased the proportion of degranulated mast cells significantly and neutrophil accumulation occurred with lengthening contractions. With bupivacaine, accumulation of neutrophils decreased by 70% when degranulation was inhibited. These results indicate that mast cells are important in the process governing leukocyte trafficking in skeletal muscle trauma and that targeting their inhibition could be an attractive alternative for control of inflammation.
Type de document: | Article publié dans une revue avec comité d'évaluation |
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Volume: | 37 |
Numéro: | 6 |
Pages: | p. 754-763 |
Version évaluée par les pairs: | Oui |
Date: | 2008 |
Sujets: | Sciences naturelles et génie > Sciences naturelles > Biologie et autres sciences connexes Sciences de la santé Sciences de la santé > Sciences de l'activité physique et réadaptation Sciences de la santé > Sciences de l'activité physique et réadaptation > Physiothérapie |
Département, module, service et unité de recherche: | Départements et modules > Département des sciences de la santé > Unité d'enseignement en physiothérapie |
Mots-clés: | Inflammation, muscle, leukocyte accumulation, mast cells, bupivacaine, CMP 48/80, cromolyn, lengthening contractions, muscle damage |
Déposé le: | 15 mars 2019 00:55 |
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Dernière modification: | 15 mars 2019 00:55 |
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