Bellila, Amor, Tremblay, Cindy, Pichette, André, Marzouk, Brahim, Mshvildadze, Vakhtang, Lavoie, Serge et Legault, Jean. (2011). Cytotoxic activity of withanolides isolated from Tunisian Datura metel L. Phytochemistry, 72, (16), p. 2031-2036.
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URL officielle: http://dx.doi.org/doi:10.1016/j.phytochem.2011.07....
Résumé
Withanolide-type steroids, withametelin Q (1) and 12α-hydroxydaturametelin B (2) along with three known withanolides, were isolated from leaves of Datura metel L. (Solanaceae). The respective structures, characterized mainly by NMR spectroscopy, were identified as (20R,22R,24R)-21,24-epoxy-1α,3β-dihydroxywitha-5,25(27)-dienolide-3-O-β-D-glucopyranoside (1) and (20R,22R,24R)-12α,21,27-trihydroxy-1-oxowitha-2,5,24-trienolide-27-O-β-D-glucopyranoside (2). The cytotoxicity of isolated compounds was evaluated against human lung carcinoma cells (A549) and human colorectal adenocarcinoma cells (DLD-1), respectively. Compound 2 exhibited cytotoxicity against A549 and DLD-1 cell lines, with IC50 values of 7 and 2.0 μM, respectively. However, for compounds 6 and 7, cytotoxicities were higher against DLD-1 cells with IC(50) values of 0.6 and 0.7 μM. Both compounds blocked the cell cycle in the S-phase and induced apoptosis.
| Type de document: | Article publié dans une revue avec comité d'évaluation |
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| ISSN: | 00319422 |
| Volume: | 72 |
| Numéro: | 16 |
| Pages: | p. 2031-2036 |
| Version évaluée par les pairs: | Oui |
| Date: | Novembre 2011 |
| Identifiant unique: | 10.1016/j.phytochem.2011.07.009 |
| Unité(s) institutionnelle(s): | Départements et unités pédagogiques > Département des sciences fondamentales |
| Mots-clés: | Datura metel, Solanaceae, cytotoxic activity, steroids, withametelin Q, 12α-hydroxydaturametelin B |
| Déposé le: | 01 sept. 2021 17:45 |
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| Dernière modification: | 01 sept. 2021 17:45 |
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