Bradette-Hébert Marie-Ève, Legault Jean, Lavoie Serge et Pichette André. (2008). A new labdane diterpene from the flowers of Solidago canadensis. Chemical & Pharmaceutical Bulletin, 56, (1), p. 82-84.
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URL officielle: http://dx.doi.org/doi:10.1248/cpb.56.82
Résumé
A new labdane diterpene, 9α,16ξ-dihydroxy-6-oxo-7,13-labdadien-15,16-olide (solicanolide, 1) and six known compounds identified as quercetin (2), 3-O-caffeoylquinic acid (3, neochlorogenic acid), 5-O-caffeoylquinic acid (4, chlorogenic acid), 4,5-di-O-caffeoylquinic acid (5), 3,5-di-O-caffeoylquinic acid (6) and 3,4-di-O-caffeoylquinic acid (7) were isolated from the flowers of Solidago canadensis. To our knowledge, compound 7 was isolated for the first time in S. canadensis. This work describes the isolation of compounds 1—7 and the structure elucidation of a new compound identified as compound 1. Solicanolide (1) showed cytotoxic activity against A549 (IC50: 13±2 μM), DLD-1 (IC50: 26±2 μM) and WS1 (IC50: 17±1 μM) cell lines.
| Type de document: | Article publié dans une revue avec comité d'évaluation |
|---|---|
| ISSN: | 0009-2363 |
| Volume: | 56 |
| Numéro: | 1 |
| Pages: | p. 82-84 |
| Version évaluée par les pairs: | Oui |
| Date: | 2008 |
| Identifiant unique: | 10.1248/cpb.56.82 |
| Sujets: | Sciences naturelles et génie > Sciences naturelles > Biologie et autres sciences connexes Sciences naturelles et génie > Sciences naturelles > Chimie |
| Département, module, service et unité de recherche: | Départements et modules > Département des sciences fondamentales |
| Mots-clés: | Solidago canadensis, isolation, labdane, solicanolide, cytotoxicity, caffeoylquinic acid |
| Déposé le: | 01 sept. 2021 17:50 |
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| Dernière modification: | 01 sept. 2021 17:50 |
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