Gauthier, Charles, Legault, Jean, Lavoie, Serge, Rondeau, Simon, Tremblay, Samuel et Pichette, André. (2009). Synthesis and cytotoxicity of bidesmosidic betulin and betulinic acid saponins. Journal of Natural Products, 72, (1), p. 72-81.
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URL officielle: http://dx.doi.org/doi:10.1021/np800579x
Résumé
The naturally occurring cytotoxic saponin 28-O-beta-d-glucopyranosylbetulinic acid 3beta-O-alpha-l-arabinopyranoside (3) was easily synthesized along with seven bidesmosidic saponins starting from the lupane-type triterpenoids betulin (1) and betulinic acid (2). As highlighted by the preliminary cytotoxicity evaluation against A549, DLD-1, MCF7, and PC-3 human cancer cell lines, the bidesmosidic betulin saponin 22a, bearing alpha-l-rhamnopyranoside moieties at both C-3 and C-28 positions, was determined to be a potent cytotoxic agent (IC(50) 1.8-1.9 microM).
| Type de document: | Article publié dans une revue avec comité d'évaluation |
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| ISSN: | 0163-3864 |
| Volume: | 72 |
| Numéro: | 1 |
| Pages: | p. 72-81 |
| Version évaluée par les pairs: | Oui |
| Date: | 2009 |
| Identifiant unique: | 10.1021/np800579x |
| Unité(s) institutionnelle(s): | Départements et unités pédagogiques > Département des sciences fondamentales |
| Mots-clés: | bidesmosidic betulin saponin, analytical apparatus, anions, carbohydrates, cancer cells, cytotoxicity |
| Déposé le: | 01 sept. 2021 18:08 |
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| Dernière modification: | 22 nov. 2023 14:34 |
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