Constellation, le dépôt institutionnel de l'Université du Québec à Chicoutimi

Résumé

Phytochemical investigations of the MeOH extract of Betula papyrifera inner bark led to the isolation of ten phenolic compounds of the following types: diarylheptanoid glycosides (1–4), a diarylheptanoid (5), a lignan (6), flavonoids (7–8) and chavicol glycosides (9–10). Among them, the diarylheptanoid glycoside, (S)-1,7-bis-(4-hydroxyphenyl)-heptan-3-one-5-O-α-l-arabinofuranosyl-(1 → 6)-β-d-glucopyranoside, papyriferoside A (1), was isolated and its structure was determined on the basis of 1D and 2D NMR, HPLC-MS, as well as high resolution mass spectroscopic data. Platyphylloside (4) exerted the strongest cytotoxic activity of all isolated compounds with IC50 values ranging from 10.3 to 13.8 μM.