Constellation, le dépôt institutionnel de l'Université du Québec à Chicoutimi

Native American admixture in the Quebec founder population

Moreau Claudia, Lefebvre Jean-François, Jomphe Michèle, Bhérer Claude, Ruiz-Linares Andres, Vézina Hélène, Roy-Gagnon Marie-Hélène et Labuda Damian. (2013). Native American admixture in the Quebec founder population. PLoS ONE, 8, (6), e65507.

[thumbnail of plos.pdf]
Prévisualisation
PDF
1MB

URL officielle: https://dx.doi.org/doi:10.1371/journal.pone.006550...

Résumé

For years, studies of founder populations and genetic isolates represented the mainstream of genetic mapping in the effort to target genetic defects causing Mendelian disorders. The genetic homogeneity of such populations as well as relatively homogeneous environmental exposures were also seen as primary advantages in studies of genetic susceptibility loci that underlie complex diseases. European colonization of the St-Lawrence Valley by a small number of settlers, mainly from France, resulted in a founder effect reflected by the appearance of a number of population-specific disease-causing mutations in Quebec. The purported genetic homogeneity of this population was recently challenged by genealogical and genetic analyses. We studied one of the contributing factors to genetic heterogeneity, early Native American admixture that was never investigated in this population before. Consistent admixture estimates, in the order of one per cent, were obtained from genome-wide autosomal data using the ADMIXTURE and HAPMIX software, as well as with the fastIBD software evaluating the degree of the identity-by-descent between Quebec individuals and Native American populations. These genomic results correlated well with the genealogical estimates. Correlations are imperfect most likely because of incomplete records of Native founders’ origin in genealogical data. Although the overall degree of admixture is modest, it contributed to the enrichment of the population diversity and to its demographic stratification. Because admixture greatly varies among regions of Quebec and among individuals, it could have significantly affected the homogeneity of the population, which is of importance in mapping studies, especially when rare genetic susceptibility variants are in play.

Type de document:Article publié dans une revue avec comité d'évaluation
ISSN:1932-6203
Volume:8
Numéro:6
Pages:e65507
Version évaluée par les pairs:Oui
Date:2013
Identifiant unique:10.1371/journal.pone.0065507
Sujets:Sciences sociales et humaines > Sciences humaines > Histoire
Sciences sociales et humaines > Sciences sociales > Démographie
Département, module, service et unité de recherche:Départements et modules > Département des sciences humaines
Mots-clés:Quebec, native American people, population genetics, genomics, Europe, computer software, gene mapping, paleogenetics
Déposé le:08 oct. 2022 16:29
Dernière modification:08 oct. 2022 16:29
Afficher les statistiques de telechargements

Éditer le document (administrateurs uniquement)

Creative Commons LicenseSauf indication contraire, les documents archivés dans Constellation sont rendus disponibles selon les termes de la licence Creative Commons "Paternité, pas d'utilisation commerciale, pas de modification" 2.5 Canada.

Bibliothèque Paul-Émile-Boulet, UQAC
555, boulevard de l'Université
Chicoutimi (Québec)  CANADA G7H 2B1
418 545-5011, poste 5630