Constellation, le dépôt institutionnel de l'Université du Québec à Chicoutimi

New estimates of intergenerational time intervals for the calculation of age and origins of mutations

Tremblay Marc et Vézina Hélène. (2000). New estimates of intergenerational time intervals for the calculation of age and origins of mutations. The American Journal of Human Genetics, 66, (2), p. 651-658.

[thumbnail of 8317.pdf]
Prévisualisation
PDF - Version publiée
443kB

URL officielle: https://dx.doi.org/doi:10.1086/302770

Résumé

Intergenerational time intervals are frequently used in human population-genetics studies concerned with the ages and origins of mutations. In most cases, mean intervals of 20 or 25 years are used, regardless of the demographic characteristics of the population under study. Although these characteristics may vary from prehistoric to historical times, we suggest that this value is probably too low, and that the ages of some mutations may have been underestimated. Analyses were performed by using the BALSAC Population Register (Quebec, Canada), from which several intergenerational comparisons can be made. Family reconstitutions were used to measure interval lengths and variations in descending lineages. Various parameters were considered, such as spouse age at marriage, parental age, and reproduction levels. Mother-child and father-child intervals were compared. Intergenerational male and female intervals were also analyzed in 100 extended ascending genealogies. Results showed that a mean value of 30 years is a better estimate of intergenerational intervals than 20 or 25 years. As marked differences between male and female interval length were observed, specific values are proposed for mtDNA, autosomal, X-chromosomal, and Y-chromosomal loci. The applicability of these results for age estimates of mutations is discussed.

Type de document:Article publié dans une revue avec comité d'évaluation
ISSN:00029297
Volume:66
Numéro:2
Pages:p. 651-658
Version évaluée par les pairs:Oui
Date:2000
Identifiant unique:10.1086/302770
Sujets:Sciences sociales et humaines > Sciences humaines > Histoire
Sciences sociales et humaines > Sciences sociales > Démographie
Sciences de la santé > Sciences médicales > Génétique
Département, module, service et unité de recherche:Départements et modules > Département des sciences humaines
Mots-clés:intergenerational intervals, generation lenght, parental age, founding mutations, genealogies, Quebec population
Déposé le:19 oct. 2022 15:06
Dernière modification:19 oct. 2022 15:06
Afficher les statistiques de telechargements

Éditer le document (administrateurs uniquement)

Creative Commons LicenseSauf indication contraire, les documents archivés dans Constellation sont rendus disponibles selon les termes de la licence Creative Commons "Paternité, pas d'utilisation commerciale, pas de modification" 2.5 Canada.

Bibliothèque Paul-Émile-Boulet, UQAC
555, boulevard de l'Université
Chicoutimi (Québec)  CANADA G7H 2B1
418 545-5011, poste 5630