Nadaraia Nanuli, Barbakadze Nana N., Kakhabrishvili Meri L. et Mshvildadze Vakhtang. (2019). Synthesis and biological activity of hydrazones of 5α-steroids. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 10, (1), p. 238-243.
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Résumé
Condensation reactions catalyzed by acetic acid of severalarylhydrazine (2,4-dinitrophenyl hydrazine) and hydrazides (hydrazides of bromobenzoic and salicylic acid, benzofuran-2- and indol-2-carboxylicacid) with 3β-acetoxy- and 3β-hydroxy-5α-pregn-16-en-20-one (1 and 2), epiandrosterone (6) and 5α-androst-2-en-17- one (9) were studied for the purpose of synthesizing potentially bioactive 5-steroidal hydrazones. The starting ketones (1,2,6,9) were synthesized on the bases of aglicon of steroidal saponine - tigogenin isolated from plant “Yucca gloriosa” introduced in Georgia. The structures of synthesized new hydrazones (3-5,7,8,10,11) were established by NMR 1H, 13C and mass-spectral data. The antiviral activity some of them (7,8,10,11) were studied.
| Type de document: | Article publié dans une revue avec comité d'évaluation |
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| Volume: | 10 |
| Numéro: | 1 |
| Pages: | p. 238-243 |
| Version évaluée par les pairs: | Oui |
| Date: | Janvier 2019 |
| Sujets: | Sciences naturelles et génie > Sciences naturelles > Biologie et autres sciences connexes Sciences naturelles et génie > Sciences naturelles > Chimie |
| Département, module, service et unité de recherche: | Unités de recherche > Centre de recherche sur la Boréalie (CREB) Départements et modules > Département des sciences fondamentales |
| Mots-clés: | steroid, hydrazone, synthesis, antiviral activity |
| Déposé le: | 31 mai 2023 13:33 |
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| Dernière modification: | 17 juill. 2023 20:07 |
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