Constellation, le dépôt institutionnel de l'Université du Québec à Chicoutimi

Résumé

The aim of the research was to study chemical composition and anti-inflammatory effect of essential oil from Salvia sclarea aerial parts growing in Georgia. It is well known that essential oils of Salvia possesses anti-inflammatory, antifungal, antioxidant, antimicrobial, cytotoxic and anti-diabetic activities. Essential oil (EO) was obtained by hydrodistillation and characterized by Gas Chromatography-Mass Spectrometry (GC-MS) technique. EO yield from areal part was 0.23%. In total, 25 different compounds of terpene nature were identified. Linalyl acetate (18.8%), linalool (14.9%) and spathulenol (9.07%) were the main components in S. sclarea essential oil. The anti-inflammatory activity of the essential oil was evaluated on a base of nitric oxide (NO) production measure in LPSstimulated RAW 264.7 murine monocyte-macrophage cells. EO exhibited high anti-inflammatory activity with 74% inhibition of NO production, at 80 µg/ml dose, without any significant toxicity.