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In vivo immune signatures of healthy human pregnancy : inherently inflammatory or anti-inflammatory?

Graham Caroline, Chooniedass Rishma, Stefura William P., Becker Allan B., Sears Malcolm R., Turvey Stuart E., Mandhane Piush J., Subbarao Padmaja, CHILD Study Investigators, Laprise Catherine et HayGlass Kent T.. (2017). In vivo immune signatures of healthy human pregnancy : inherently inflammatory or anti-inflammatory? PLoS ONE, 12, (6), e0177813.

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URL officielle: https://doi.org/10.1371/journal.pone.0177813

Résumé

Changes in maternal innate immunity during healthy human pregnancy are not well understood. Whether basal immune status in vivo is largely unaffected by pregnancy, is constitutively biased towards an inflammatory phenotype (transiently enhancing host defense) or exhibits anti-inflammatory bias (reducing potential responsiveness to the fetus) is unclear. Here, in a longitudinal study of healthy women who gave birth to healthy infants following uncomplicated pregnancies within the Canadian Healthy Infant Longitudinal Development (CHILD) cohort, we test the hypothesis that a progressively altered bias in resting innate immune status develops. Women were examined during pregnancy and again, one and/or three years postpartum. Most pro-inflammatory cytokine expression, including CCL2, CXCL10, IL-18 and TNFα, was reduced in vivo during pregnancy (20–57%, p<0.0001). Anti-inflammatory biomarkers (sTNF-RI, sTNF-RII, and IL-1Ra) were elevated by ~50–100% (p<0.0001). Systemic IL-10 levels were unaltered during vs. post-pregnancy. Kinetic studies demonstrate that while decreased pro-inflammatory biomarker expression (CCL2, CXCL10, IL-18, and TNFα) was constant, anti-inflammatory expression increased progressively with increasing gestational age (p<0.0001). We conclude that healthy resting maternal immune status is characterized by an increasingly pronounced bias towards a systemic anti-inflammatory innate phenotype during the last two trimesters of pregnancy. This is resolved by one year postpartum in the absence of repeat pregnancy. The findings provide enhanced understanding of immunological changes that occur in vivo during healthy human pregnancy.

Type de document:Article publié dans une revue avec comité d'évaluation
Volume:12
Numéro:6
Pages:e0177813
Version évaluée par les pairs:Oui
Date:2017
Sujets:Sciences de la santé > Sciences médicales > Biologie moléculaire
Sciences de la santé > Sciences médicales > Génétique
Sciences de la santé > Sciences médicales > Immunologie
Département, module, service et unité de recherche:Départements et modules > Département des sciences fondamentales
Mots-clés:pregnancy, immunological changes, pro-inflammatory, anti-inflammatory, biomarkers, immunology, inflammation, maternal immune system
Déposé le:26 juin 2017 16:46
Dernière modification:26 juin 2017 16:46
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