Lavoie Serge, Gauthier Charles, Legault Jean, Mercier Sylvain, Mshvildadze Vakhtang et Pichette André. (2013). Lanostane- and cycloartane-type triterpenoids from Abies balsamea oleoresin. Beilstein Journal of Organic Chemistry, 9, p. 1333-1339.
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URL officielle: http://dx.doi.org/10.3762/bjoc.9.150
Résumé
Phytochemical analysis of A. balsamea oleoresin led to the isolation of three new 3,4-seco-lanostane triterpenoids 1-3, one new cycloartane triterpenoid 4 along with fourteen known terpenoids. Structure determinations were based on extensive 1D/2D NMR, IR and MS spectroscopic analyses, and comparison with literature data. The isolated compounds were evaluated in vitro for their cytotoxicity against human cell lines (A549, DLD-1, WS1) and their antibacterial activity against E. coli and S. aureus. Abiesonic acid (6) exhibited weak cytotoxic activity against A549 (IC50 = 22 mu M) while compounds 1 and 4 were weakly active against S. aureus (MIC = 25 mu M).
| Type de document: | Article publié dans une revue avec comité d'évaluation |
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| ISSN: | 1860-5397 |
| Volume: | 9 |
| Pages: | p. 1333-1339 |
| Version évaluée par les pairs: | Oui |
| Date: | 2013 |
| Identifiant unique: | 10.3762/bjoc.9.150 |
| Sujets: | Sciences naturelles et génie > Sciences naturelles > Chimie Sciences de la santé > Sciences médicales > Pharmacologie |
| Département, module, service et unité de recherche: | Départements et modules > Département des sciences fondamentales |
| Mots-clés: | Abies balsamea, cycloartane, lanostane, oleoresin, triterpenoids |
| Déposé le: | 26 janv. 2016 01:02 |
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| Dernière modification: | 05 déc. 2016 21:01 |
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