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Clustering of the metabolic syndrome components in adolescence : role of visceral fat

Melka Melkaye G., Abrahamowicz Michal, Leonard Gabriel T., Perron Michel, Richer Louis, Veillette Suzanne, Gaudet Daniel, Paus Tomáš et Pausova Zdenka. (2013). Clustering of the metabolic syndrome components in adolescence : role of visceral fat. PLoS ONE, 8, (12),

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Visceral fat (VF) promotes the development of metabolic syndrome (MetS), which emerges as early as in adolescence. The clustering of MetS components suggests shared etiologies, but these are largely unknown and may vary between males and females. Here, we investigated the latent structure of pre-clinical MetS in a community-based sample of 286 male and 312 female adolescents, assessing their abdominal adiposity (VF) directly with magnetic resonance imaging. Principal component analysis of the five MetS-defining variables (VF, blood pressure [BP], fasting serum triglycerides, HDL-cholesterol and glucose) identified two independent components in both males and females. The first component was sex-similar; it explained >30% of variance and was loaded by all but BP variables. The second component explained >20% of variance; it was loaded by BP similarly in both sexes but additional loading by metabolic variables was sex-specific. This sex-specificity was not detected in analyses that used waist circumference instead of VF. In adolescence, MetS-defining variables cluster into at least two sub-syndromes: (1) sex-similar metabolic abnormalities of obesity-induced insulin resistance and (2) sex-specific metabolic abnormalities associated with BP elevation. These results suggest that the etiology of MetS may involve more than one pathway and that some of the pathways may differ between males and females. Further, the sex-specific metabolic abnormalities associated with BP elevation suggest the need for sex-specific prevention and treatment strategies of MetS.

Type de document:Article publié dans une revue avec comité d'évaluation
Version évaluée par les pairs:Oui
Date:Décembre 2013
Sujets:Sciences de la santé
Sciences de la santé > Sciences médicales
Département, module, service et unité de recherche:Départements et modules > Département des sciences de la santé > Module de psychologie
Mots-clés:visceral fat, metabolic syndrome, adolescence, abdominal adiposity, magnetic resonance imaging, sex diferenciation, tissu adipeux, syndrome métabolique, adiposité abdominale, imagerie par résonance magnétique, différence entre les sexes
Déposé le:20 avr. 2016 21:43
Dernière modification:18 juill. 2023 19:53
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