Gepdiremen Akçahan, Mshvildadze Vakhtang, Süleyman Halis et Elias Riad. (2004). Acute and chronic antiinflammatory effects of Hedera colchica in rats. Journal of Ethnopharmacology, 94, (1), p. 191-195.
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URL officielle: http://dx.doi.org/doi:10.1016/j.jep.2004.06.001
Résumé
Hedera helix and Hedera colchica are the members of Araliaceae family. In the present study, we tested the possible antiinflammatory effects of crude (CSE) and purified (SPE) extracts of Hedera colchica in carrageenan- and cotton pellet-induced acute and chronic inflammation models in rats. Both CSE and SPE of Hedera colchica were found to have antiinflammatory effects. The most potent drug was found as indomethacin (90%) in the 4 h measurements, while SPE (83%) and CSE (55%) of Hedera colchica in 100 mg/kg doses were found to have quite potent effects in acute phase of inflammation, in respect to control values. For testing chronic antiinflammatory (antiproliferative) effects, cotton pellet granuloma test was conducted. SPE was found as the most potent drug in chronic phase of inflammation with an effect of 64.32%. Indomethacin was found more potent than the CSE of Hedera colchica, and potency was found as 61.2 and 58%, respectively.
Type de document: | Article publié dans une revue avec comité d'évaluation |
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ISSN: | 03788741 |
Volume: | 94 |
Numéro: | 1 |
Pages: | p. 191-195 |
Version évaluée par les pairs: | Oui |
Date: | 2004 |
Identifiant unique: | 10.1016/j.jep.2004.06.001 |
Sujets: | Sciences naturelles et génie > Sciences naturelles > Biologie et autres sciences connexes Sciences naturelles et génie > Sciences naturelles > Chimie Sciences de la santé > Sciences médicales > Pharmacologie |
Département, module, service et unité de recherche: | Départements et modules > Département des sciences fondamentales Unités de recherche > Centre de recherche sur la Boréalie (CREB) |
Mots-clés: | Araliaceae, carrageenan, cotton pellet, Hedera colchica, inflammation, saponin |
Déposé le: | 07 juin 2023 13:33 |
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Dernière modification: | 07 juin 2023 13:33 |
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