Gepdiremen A., Mshvildadze Vakhtang, Süleyman H. et Elias Riad. (2005). Acute anti-inflammatory activity of four saponins isolated from ivy: alpha-hederin, hederasaponin-C, hederacolchiside-E and hederacolchiside-F in carrageenan-induced rat paw edema. Phytomedicine, 12, (6-7), p. 440-444.
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URL officielle: http://dx.doi.org/doi:10.1016/j.phymed.2004.04.005
Résumé
The anti-inflammatory potential of α-hederin (monodesmoside) and hederasaponin-C from Hedera helix, and hederacolchisides-E and -F (bidesmosides) from H. colchica was investigated in carrageenan-induced acute paw edema in rats. Saponins and indomethacin were given orally in concentrations of 0.02 and 20 mg/kg body wt. For the first phase of acute inflammation, indomethacin was found as the most potent drug. α-hederin and hederasaponin-C were found ineffective, while hederacolchisides-E and -F showed slight anti-inflammatory effects on the first phase. For the second phase of acute inflammation, indomethacin and hederacolchiside-F were determined as very potent compounds. α-hederin was found ineffective for the second phase, either. Despite hederasaponin-C and -E were found effective in the second phase of inflammation, they were not found as effective as indomethacin and hederacolchiside-F. As a conclusion, hederasaponin-C, -E and -F, may exert their anti-inflammatory effects by blocking bradykinin or other inflammation mediators. The latter affect may occur via affecting prostaglandin pathways. Regarding the structure activity relationship, it is likely that sugars at C3 position and Rha7-Glc1-6Glc moiety at C28 position are essential for the acute anti-inflammatory effect.
Type de document: | Article publié dans une revue avec comité d'évaluation |
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ISSN: | 09447113 |
Volume: | 12 |
Numéro: | 6-7 |
Pages: | p. 440-444 |
Version évaluée par les pairs: | Oui |
Date: | 2005 |
Identifiant unique: | 10.1016/j.phymed.2004.04.005 |
Sujets: | Sciences naturelles et génie > Sciences naturelles > Biologie et autres sciences connexes Sciences naturelles et génie > Sciences naturelles > Chimie Sciences de la santé > Sciences médicales > Pharmacologie |
Département, module, service et unité de recherche: | Départements et modules > Département des sciences fondamentales Unités de recherche > Centre de recherche sur la Boréalie (CREB) |
Mots-clés: | α-hederin, anti-inflammatory activity, carrageenan, hederacolchiside, hederasaponin, saponins of ivy, Hedera helix |
Déposé le: | 07 juin 2023 13:37 |
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Dernière modification: | 07 juin 2023 13:37 |
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