Constellation, le dépôt institutionnel de l'Université du Québec à Chicoutimi

Visceral adiposity is associated with metabolic profiles predictive of type 2 diabetes and myocardial infarction

Raheem Javeria, Sliz Eeva, Shin Jean, Holmes Michael V., Pike G. Bruce, Richer Louis, Gaudet Daniel, Paus Tomáš et Pausova Zdenka. (2022). Visceral adiposity is associated with metabolic profiles predictive of type 2 diabetes and myocardial infarction. Communications Medicine, 2, (1),

[thumbnail of s43856-022-00140-5.pdf]
PDF - Version publiée
Disponible sous licence Creative Commons : Attribution (CC-BY 2.5).


URL officielle:


Background: Visceral fat (VF) increases risk for cardiometabolic disease (CMD), the leading cause of morbidity and mortality. Variations in the circulating metabolome predict the risk for CMD but whether or not this is related to VF is unknown. Further, CMD is now also present in adolescents, and the relationships between VF, circulating metabolome, and CMD may vary between adolescents and adults.

Methods: With an aim to add understanding to the metabolic variations in visceral obesity, we tested associations between VF, measured directly with magnetic resonance imaging, and 228 fasting serum metabolomic measures, quantified with nuclear magnetic resonance spectroscopy, in 507 adults (36-65 years) and 938 adolescents (12-18 years). We further utilized data from published studies to estimate similarities between VF and CMD-associated metabolic profiles.

Results: Here we show that VF, independently of body mass index (BMI) or subcutaneous fat, is associated with triglyceride-rich lipoproteins, fatty acids, and inflammation in both adults and adolescents, whereas the associations with amino acids, glucose, and intermediary metabolites are significant in adults only. BMI-adjusted metabolomic profile of VF resembles those predicting type 2 diabetes in adults (R 2 = 0.88) and adolescents (R 2 = 0.70), and myocardial infarction in adults (R 2 = 0.59) and adolescents (R 2 = 0.40); this is not the case for ischemic stroke (adults: R 2 = 0.05, adolescents: R 2 = 0.08).

Conclusions: Visceral adiposity is associated with metabolomic profiles predictive of type 2 diabetes and myocardial infarction even in normal-weight individuals and already in adolescence. Targeting factors contributing to the emergence and maintenance of these profiles might ameliorate their cumulative effects on cardiometabolic health.

Type de document:Article publié dans une revue avec comité d'évaluation
Version évaluée par les pairs:Oui
Identifiant unique:10.1038/s43856-022-00140-5
Sujets:Sciences sociales et humaines > Sciences sociales > Psychologie
Sciences de la santé
Sciences de la santé > Sciences médicales
Département, module, service et unité de recherche:Départements et modules > Département des sciences de la santé > Module de psychologie
Mots-clés:dyslipidaemias, obesity, visceral fat, visceral adiposity, visceral obesity
Déposé le:08 avr. 2023 18:05
Dernière modification:18 juill. 2023 19:51
Afficher les statistiques de telechargements

Éditer le document (administrateurs uniquement)

Creative Commons LicenseSauf indication contraire, les documents archivés dans Constellation sont rendus disponibles selon les termes de la licence Creative Commons "Paternité, pas d'utilisation commerciale, pas de modification" 2.5 Canada.

Bibliothèque Paul-Émile-Boulet, UQAC
555, boulevard de l'Université
Chicoutimi (Québec)  CANADA G7H 2B1
418 545-5011, poste 5630