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Polyamide microparticles containing vitamin C by interfacial polymerization : an approach by design of experimentation

Ripoll Lionel et Clement Yohann. (2016). Polyamide microparticles containing vitamin C by interfacial polymerization : an approach by design of experimentation. Cosmetics, 3, (4), p. 1-17.

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URL officielle: http://dx.doi.org/doi:10.3390/cosmetics3040038

Résumé

Vitamin C is widely use in cosmetics and pharmaceutics products for its active properties. However ascorbic acid shows unfavourable chemical instability such as oxidation leading to formulation problems. Therefore, carriers, such as micro- and nanoparticles, have been widely investigated as delivery systems for vitamin C to improve its beneficial effects in skin treatment. However, none of the previous studies have been able to produce microparticles with a high encapsulation entrapment of vitamin C. The aim of the present study is to use an experimental design to optimize the synthesis of polyamide microparticles for the delivery of ascorbic acid. The effect of four formulation parameters on microparticles properties (size and morphology, encapsulation efficiency and yield, release kinetics) were investigated using a surface response design. Finally, we were able to obtain stable microparticles containing more than 65% of vitamin C. This result confirms the effectiveness of using design of experiments for the optimisation of microparticle formulation and supports the proposal of using them as candidate for the delivery of vitamin C in skin treatment.

Type de document:Article publié dans une revue avec comité d'évaluation
Volume:3
Numéro:4
Pages:p. 1-17
Version évaluée par les pairs:Oui
Date:2016
Sujets:Sciences naturelles et génie > Sciences naturelles > Chimie
Sciences de la santé > Sciences médicales > Dermatologie
Département, module, service et unité de recherche:Départements et modules > Département des sciences fondamentales
Mots-clés:microparticles, design of experiments, vitamin C, polymerization, antioxidants
Déposé le:10 nov. 2016 00:02
Dernière modification:10 nov. 2016 00:02
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