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Bone mineral density in independent elderly women with different physical and functional profiles and vitamin D receptor gene polymorphisms

Merli Myriam Fernanda, Poli Fredico Regina Célia, Ruzzon Emily Delalibera, da Silva Rubens Alexandre, Parron Fernandes Karen Barros, Teixeira Denilson de Castro, de Souza Marquez Audrey et Probst Vanessa Suziane. (2016). Bone mineral density in independent elderly women with different physical and functional profiles and vitamin D receptor gene polymorphisms. Brazilian journal of kinanthropometry and human performance, 18, (1), p. 20-31.

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URL officielle: http://dx.doi.org/10.5007/1980-0037.2016v18n1p20

Résumé

The aim of the study was to compare BMD among physically independent elderly women with different physical-functional profiles and vitamin D receptor gene (VDR) polymorphisms, as well as to analyze the effect of the interaction between these last two aspects on BMD. Overall, 165 elderly women had BMD assessed by bone densitometry. Handgrip and lower limb strength and functional exercise capacity (6MWT) were also assessed. VDR polymorphisms (TaqI, BsmI, ApaI and FokI) were analyzed by polymerase chain reaction. For analyses, elderly women were categorized according to their performance on physical-functional tests into low performance (LP; <25th percentile), normal performance (NP; 25th percentile ≤ NP ≤ 75th percentile) and high performance (HP;> 75th percentile). Regarding functional exercise capacity, LP group showed lower BMD compared to HP and NP groups (p=0,003). With respect to handgrip strength, there was a trend for LP group to have lower bone mineral density compared to NP group (p=0.08). No differences were observed in femur and lumbar BMD in comparisons among the different VDR genotypes (0.07≤p≤0.94); among different groups regarding lower limb strength (p=0.49) and in the interaction analysis among variables (0.17≤p≤0.77). It was concluded that physically independent elderly women with low functional exercise capacity have lower bone mineral density than those classified as normal and high performance. However, apparently, there is no effect of the interaction between VDR gene polymorphisms and physical and functional factors on BMD.

Type de document:Article publié dans une revue sans comité d'évaluation
Volume:18
Numéro:1
Pages:p. 20-31
Date:2016
Sujets:Sciences de la santé
Sciences de la santé > Sciences de l'activité physique et réadaptation
Sciences de la santé > Sciences de l'activité physique et réadaptation > Physiothérapie
Sciences de la santé > Sciences médicales
Département, module, service et unité de recherche:Départements et modules > Département des sciences de la santé > Unité d'enseignement en physiothérapie
Mots-clés:elderly, bone density, exercise tolerance, genetics, personne âgées, densité osseuse, tolérance à l'effort, génétique
Déposé le:13 oct. 2017 01:20
Dernière modification:13 oct. 2017 01:20
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Creative Commons LicenseSauf indication contraire, les documents archivés dans Constellation sont rendus disponibles selon les termes de la licence Creative Commons "Paternité, pas d'utilisation commerciale, pas de modification" 2.5 Canada.

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