Gagné-Ouellet Valérie, Guay Simon-Pierre, Boucher-Lafleur Anne-Marie, Bouchard Luigi et Laprise Catherine. (2015). DNA methylation signature of interleukin 1 receptor type II in asthma. Clinical Epigenetics, 7, p. 80.
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URL officielle: http://www.clinicalepigeneticsjournal.com/content/...
Résumé
Interleukin 1 and its receptors are associated with allergic diseases such as asthma. In the present study, we measured DNA methylation at the IL1R1 and IL1R2 gene loci and assessed for associations with asthma-related phenotypes and gene expressions. We found that asthmatic and atopic individuals have higher IL1R2 promoter DNA methylation than control subjects. Additionally, we observed a negative correlation between DNA methylation at the IL1R2 promoter and IL1R2 mRNA expression. These results suggest for the first time that IL1R2 promoter DNA methylation is associated with its gene repression in allergic diseases such as asthma.
| Type de document: | Article publié dans une revue avec comité d'évaluation |
|---|---|
| Volume: | 7 |
| Pages: | p. 80 |
| Version évaluée par les pairs: | Oui |
| Date: | 2015 |
| Sujets: | Sciences de la santé > Sciences médicales > Biologie moléculaire Sciences de la santé > Sciences médicales > Génétique |
| Département, module, service et unité de recherche: | Départements et modules > Département des sciences fondamentales |
| Mots-clés: | Asthma, Atopy, Epigenetics, IL1, IL1R1, IL1R2, Methylation, Interleukin 1, Interleukin 1 receptor type 1, Interleukin 1 receptor type 2, asthme, atopie, épigénétique |
| Informations complémentaires: | This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| Déposé le: | 28 août 2015 15:27 |
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| Dernière modification: | 05 déc. 2016 21:08 |
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