Bchetnia Mbarka, Lacroix Jacynthe, Farez Tarik, Larouche Miriam, Powell Julie, McCuaig Catherine, Dupéré Audrey, Morin Charles, Legendre-Guillemin Valérie et Laprise Catherine. (2015). Reduction of keratin aggregates in epidermolysis bullosa simplex keratinocytes after pretreatment with trimethylamine N-oxide. Experimental dermatology, 25, (3), p. 229-230.
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URL officielle: http://dx.doi.org/doi:10.1111/exd.12821
Résumé
Epidermolysis bullosa simplex (EBS) is a dominantly inherited skin disease caused by mutations in the keratin 5 (KRT5) or KRT14 genes (1). Some reports suggested that fever and/or hot weather may exacerbate EBS phenotype (2). Effective EBS therapies are still lacking. Molecular chaperones are proteins whose main function is to promote the correct folding of polypeptides (s1). Molecules such as trimethylamine N-oxide (TMAO) and sodium 4-phenylbutyrate (4-PBA) act as chemical chaperones (s2) with protein folding and stabilization activities (s3, s4, s5).
| Type de document: | Article publié dans une revue avec comité d'évaluation |
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| ISSN: | 1600-0625 |
| Volume: | 25 |
| Numéro: | 3 |
| Pages: | p. 229-230 |
| Version évaluée par les pairs: | Oui |
| Date: | 2015 |
| Sujets: | Sciences de la santé > Sciences médicales > Dermatologie Sciences de la santé > Sciences médicales > Génétique |
| Département, module, service et unité de recherche: | Départements et modules > Département des sciences fondamentales |
| Mots-clés: | epidermolysis bullosa simplex, keratin aggregates, TMAO, 4-PBA, épidermolyse bulleuse simple, agrégats de kératine, oxyde de triméthylamine, trimethylamine N-oxide, sodium 4-phenylbutyrate |
| Informations complémentaires: | This is the peer reviewed version of the following article: « Bchetnia M, Lacroix J, Farez T, Larouche M, Powell J, McCuaig C, Dupéré A, Morin C, Legendre-Guillemin V et Laprise C. 2015. Reduction of keratin aggregates in epidermolysis bullosa simplex keratinocytes after pretreatment with trimethylamine N-oxide. Experimental Dermatology », which has been published in final form at http://dx.doi.org/10.1111/exd.12821. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
| Déposé le: | 26 janv. 2016 01:17 |
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| Dernière modification: | 15 mars 2019 15:14 |
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