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Functional classes of bronchial mucosa genes that are differentially expressed in asthma

Laprise Catherine, Sladek Robert, Ponton André, Bernier Marie-Claude, Hudson Thomas J. et Laviolette Michel. (2004). Functional classes of bronchial mucosa genes that are differentially expressed in asthma. BMC genomics, 5, (1), p. 21.

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BACKGROUND Asthma pathogenesis and susceptibility involves a complex interplay between genetic and environmental factors. Their interaction modulates the airway inflammation and remodelling processes that are present even in mild asthma and governs the appearance and severity of symptoms of airway hyperresponsiveness. While asthma is felt to develop as the result of interaction among many different genes and signalling pathways, only a few genes have been linked to an increased risk of developing this condition.

RESULTS We report the results of expression microarray studies using tissue obtained from bronchial biopsies of healthy controls and of subjects with allergic asthma, both before and following inhaled corticotherapy. We identified 79 genes that show significant differences in expression (following Bonferroni cutoff using p < 6.6 x 10(-6) to correct for multiple testing) in asthmatics compared to controls at significance levels. These included 21 genes previously implicated in asthma, such as NOS2A and GPX3, as well as new potential candidates, such as ALOX15, CTSC and CX3CR1. The expression levels of one third of these transcripts were partially or completely corrected following inhaled corticosteroid therapy.

CONCLUSION The study shows that bronchial biopsies obtained from healthy and asthmatic subjects display distinct expression profiles. These differences provide a global view of physiopathologic processes active in the asthmatic lung and may provide invaluable help to clarify the natural history of asthma.

Type de document:Article publié dans une revue avec comité d'évaluation
Pages:p. 21
Version évaluée par les pairs:Oui
Date:23 Mars 2004
Sujets:Sciences naturelles et génie > Sciences naturelles > Biologie et autres sciences connexes
Sciences de la santé > Sciences médicales > Génétique
Sciences de la santé > Sciences médicales > Pathologie
Sciences de la santé > Sciences médicales > Physiologie
Département, module, service et unité de recherche:Départements et modules > Département des sciences fondamentales
Mots-clés:microarrays, asthma, corticotherapy, bronchial biopsies, genetics, genetic predisposition, physiopathology
Déposé le:26 janv. 2016 01:08
Dernière modification:05 déc. 2016 20:49
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