Morin Andréanne, Laviolette Michel, Pastinen Tomi, Boulet Louis-Philippe et Laprise Catherine. (2017). Combining omics data to identify genes associated with allergic rhinitis. Clinical Epigenetics, 9, (1), p. 1-6.
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URL officielle: http://dx.doi.org/doi:10.1186/s13148-017-0310-1
Résumé
Allergic rhinitis is a common chronic disorder characterized by immunoglobulin E-mediated inflammation. To identify new genes associated with this trait, we performed genome- and epigenome-wide association studies and linked marginally significant CpGs located in genes or its promoter and SNPs located 1 Mb from the CpGs, by identifying cis methylation quantitative trait loci (mQTL). This approach relies on functional cellular aspects rather than stringent statistical correction. We were able to identify one gene with significant cis-mQTL for allergic rhinitis, caudal-type homeobox 1 (CDX1). We also identified 11 genes with marginally significant cis-mQTLs (p < 0.05) including one with both allergic rhinitis with or without asthma (RNF39). Moreover, most SNPs identified were not located closest to the gene they were linked to through cis-mQTLs counting the one linked to CDX1 located in a gene previously associated with asthma and atopic dermatitis. By combining omics data, we were able to identify new genes associated with allergic rhinitis and better assess the genes linked to associated SNPs.
Type de document: | Article publié dans une revue avec comité d'évaluation |
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Volume: | 9 |
Numéro: | 1 |
Pages: | p. 1-6 |
Version évaluée par les pairs: | Oui |
Date: | 2017 |
Sujets: | Sciences de la santé > Sciences médicales > Biologie moléculaire Sciences de la santé > Sciences médicales > Génétique |
Département, module, service et unité de recherche: | Départements et modules > Département des sciences fondamentales |
Mots-clés: | Allergic rhinitis, asthma, EWAS, epigenome-wide association study, GWAS, genome-wide association study, mQTLs, methylation quantitative trait loci, omics |
Informations complémentaires: | Creative Commons Attribution 4.0 |
Déposé le: | 05 avr. 2017 20:53 |
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Dernière modification: | 05 avr. 2017 21:08 |
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