Constellation, le dépôt institutionnel de l'Université du Québec à Chicoutimi

Résumé

Biofilm formation on both animate and inanimate surfaces serves as an ideal bacterial reservoir for the spread of nosocomial infections. Designing surfaces with both superhydrophobic and antibacterial properties can help reduce initial bacterial attachment and subsequent biofilm formation. In the present study, a two-step approach is deployed to fabricate silver–polymethylhydrosiloxane (Ag–PMHS) nanocomposites, followed by a simple dip-coating deposition on anodized Al. Ag-nanoparticles (Ag-NPs) are synthesized in situ within a PMHS polymeric matrix. Morphological features of Ag–PMHS coating observed by scanning electron microscopy shows heterogeneous micro–nano-structures. The chemical compositions of these coatings were characterized using X-ray diffraction and attenuated total reflection-Fourier transform infrared spectroscopy, which indicate the presence of a low-energy PMHS polymer. The as-synthesized Ag–PMHS nanocomposite demonstrated excellent antibacterial properties against clinically relevant planktonic bacteria with zone of inhibition values of 25.3 ± 0.5, 24.8 ± 0.5, and 23.3 ± 3.6 mm for Pseudomonas aeruginosa (P.A) (Gram −ve), Escherichia coli (E. coli) (Gram −ve), and Staphylococcus aureus (S.A) (Gram +ve), respectively. The Ag–PMHS nanocomposite coating on anodized Al provides an anti-biofouling property with an adhesion reduction of 99.0, 99.5, and 99.3% for Pseudomomas aeruginosa (P.A), E. coli, and S. aureus (S.A), respectively. Interestingly, the coating maintained a stable contact angle of 158° after 90 days of immersion in saline water (3.5 wt % NaCl, pH 7.4). The Ag–PMHS nanocomposite coating on anodized Al described herein demonstrates excellent antibacterial and anti-biofouling properties owing to its inherent superhydrophobic property.