Madore Anne-Marie, Houde Louis, Vézina Hélène, Vohl M.-C., Pérusse L., Mior N., Connelly P.W., Laberge C., Gaudet D. et Laprise Catherine. (2007). Contribution of hierarchical clustering techniques to the modeling of the geographic distribution of genetic polymorphisms associated with chronic inflammatory diseases in the Québec population. Public Health Genomics, 10, (4), p. 218-226.
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URL officielle: https://dx.doi.org/doi:10.1159/000106560
Résumé
Objectives: The purpose of this project was to evaluate the potential of the downward hierarchical clustering analysis (DHCA) for studying genetic heterogeneity, i.e. differences in allele frequency in subpopulations, such as the 15 public health regions of the province of Québec (Canada).
Methods: The study relied on an anonymized sample of 1,680 individuals who had participated in the Québec Heart Health Survey in 1990-1991. The genotyping of 11 variants in 8 candidate genes known to be involved in chronic inflammatory diseases, namely asthma and cardiovascular diseases, was performed using the amplification refractory mutation system and restriction fragment length polymorphism techniques. Only variants showing an allelic frequency >2% in the Québec Heart Health Survey (n = 8) were selected. DHCA techniques were then applied to model the geographical distribution of these 8 genetic variants in 15 Québec public health regions and to study genetic heterogeneity.
Results: The DHCA allowed to group public health regions and gene variants on the basis of genetic variability. For both asthma and cardiovascular diseases, 3 significant clusters of public health regions and 1 cluster of gene variants were identified.
Discussion: This study suggests that DHCA might be useful in studying genetic heterogeneity at the population level and for public health activities.
| Type de document: | Article publié dans une revue avec comité d'évaluation |
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| ISSN: | 1662-4246 |
| Volume: | 10 |
| Numéro: | 4 |
| Pages: | p. 218-226 |
| Version évaluée par les pairs: | Oui |
| Date: | 2007 |
| Identifiant unique: | 10.1159/000106560 |
| Sujets: | Sciences sociales et humaines > Sciences humaines > Histoire Sciences sociales et humaines > Sciences sociales > Démographie Sciences de la santé > Sciences médicales > Génétique |
| Département, module, service et unité de recherche: | Départements et modules > Département des sciences humaines |
| Mots-clés: | asthma, cardiovascular diseases, French Canadian population, genetic risk factors, génétique, Québec, maladies inflammatoires chroniques |
| Déposé le: | 12 oct. 2022 19:12 |
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| Dernière modification: | 13 juill. 2023 18:59 |
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