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Association study of genes associated to asthma in a specific environment, in an asthma familial collection located in a rural area influenced by different industries

Morin Andréanne, Brook Jeffrey R., Duchaine Caroline et Laprise Catherine. (2012). Association study of genes associated to asthma in a specific environment, in an asthma familial collection located in a rural area influenced by different industries. International Journal of Environmental Research and Public Health, 9, (8), p. 2620-2635.

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URL officielle: http://dx.doi.org/doi:10.3390/ijerph9082620

Résumé

Eight candidate genes selected in this study were previously associated with gene-environment interactions in asthma in an urban area. These genes were analyzed in a familial collection from a founder and remote population (Saguenay–Lac-Saint-Jean; SLSJ) located in an area with low air levels of ozone but with localized areas of relatively high air pollutant levels, such as sulphur dioxide, when compared to many urban areas. Polymorphisms (SNPs) were extracted from the genome-wide association study (GWAS) performed on the SLSJ familial collection. A transmission disequilibrium test (TDT) was performed using the entire family sample (1,428 individuals in 254 nuclear families). Stratification according to the proximity of aluminium, pulp and paper industries was also analyzed. Two genes were associated with asthma in the entire sample before correction (CAT and NQO1) and one was associated after correction for multiple analyses (CAT). Two genes were associated when subjects were stratified according to the proximity of aluminium industries (CAT and NQO1) and one according to the proximity of pulp and paper industries (GSTP1). However, none of them resisted correction for multiple analyses. Given that the spatial pattern of environmental exposures can be complex and inadequately represented by a few stationary monitors and that exposures can also come from sources other than the standard outdoor air pollution (e.g., indoor air, occupation, residential wood smoke), a new approach and new tools are required to measure specific and individual pollutant exposures in order to estimate the real impact of gene-environment interactions on respiratory health.

Type de document:Article publié dans une revue avec comité d'évaluation
Volume:9
Numéro:8
Pages:p. 2620-2635
Version évaluée par les pairs:Oui
Date:Août 2012
Sujets:Sciences naturelles et génie > Sciences appliquées > Eau et environnement
Sciences de la santé > Sciences médicales > Biologie moléculaire
Sciences de la santé > Sciences médicales > Génétique
Département, module, service et unité de recherche:Départements et modules > Département des sciences fondamentales
Mots-clés:asthma, gene-environment interactions, aluminium industries, pulp and paper industries, air pollution
Déposé le:03 févr. 2016 00:51
Dernière modification:05 déc. 2016 20:59
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